Eliza Tsou, PhD
She/Her
Assistant Professor
Medicine
My research focuses on examining the epigenetic mechanisms in the pathogenesis of autoimmune diseases, with a specific interest in vascular complications in systemic sclerosis (scleroderma). By applying unbiased-epigenomics and bioinformatics methodologies, followed by functional studies to identify relevant pathways and targets pertinent to the disease, my goal is to identify novel cellular and signaling mechanisms that define scleroderma pathogenesis and progression, patient heterogeneity, and response to therapy.
Research Area(s)
vascular biology
Publications
- Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma
- Targeting the myofibroblast genetic switch: Inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury
- Scleroderma keratinocytes promote fibroblast activation independent of transforming growth factor beta
Grants
- Funded by: TSOU, Eliza
- Principal investigator of: BET bromodomain proteins in scleroderma fibrosis
- Principal investigator of: Sirtuin1 controls endothelial angiogenic functions in scleroderma