Joshi Alumkal
Wicha Family Professor of Oncology and Professor of Internal Medicine; Prostate/GU Oncology Section Head; Associate Heme-Onc Division Chief for Basic Research
Internal Medicine
Medicine
MD, Baylor College of Medicine
Residency, UT Southwestern Medical Center
Post-doctoral fellowship in cancer epigenetics, Jim Herman Laboratory at Johns Hopkins University
Joshi Alumkal is a physician-scientist. The Alumkal Laboratory’s main emphasis is to understand how genomic and epigenomic changes contribute to lethal prostate cancer progression. They use biochemical, genomic, and epigenomic approaches in cellular models to clarify mechanisms by which key transcriptional regulators function. The most important goals of Alumkal’s studies are to identify therapies that effectively target and interdict lethal prostate cancer progression and to conduct innovative clinical trials designed to validate the molecular and clinical effectiveness of novel therapeutic agents.
Projects:
Precision therapy for prostate cancer
University Affiliation(s)
Rogel Cancer Center
Research Area(s)
Basic and Translational cancer research | Genetics / Genomics / other OMICS | Systems biology | Targeted therapies
Publications
- CHFR methylation strongly correlates with methylation of DNA damage repair and apoptotic pathway genes in non-small cell lung cancer
- Analysis of circulating cell-free DnA identifies multiclonal heterogeneity of BRCA2 reversion mutations associated with resistance to PARP inhibitors
- Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer
Grants
- Funded by: ALUMKAL, Joshi
- Funded by: ALUMKAL, Joshi
- Funded by: ALUMKAL, Joshi