Alex (Lam) Tsoi, PhD
Assistant Professor
Medicine, Public Health
Dr. Tsoi completed his PhD in biomedical science at the Medical University of South Carolina, supervised by Dr. W Jim Zheng. His PhD work focused on developing data integration approaches to enhance prioritization and interpretation of high throughput experimental results. Dr. Tsoi then worked as a research fellow in the Center for Statistical Genetics from the Department of Biostatistics at the University of Michigan. He has been working with Dr. Goncalo Abecasis and Dr. James T Elder on a variety of genetics and genomics projects for psoriasis. He joined the Department of Dermatology, Department of Computational Medicine & Bioinformatics, and the Department of Biostatistics at the University of Michigan between 2015-2016 as a faculty. Dr. Tsoi has strong interests in investigating the pathology and genetic architecture of complex cutaneous disorders using systems biology approaches. Working with Drs. James T. Elder and Johann E Gudjonsson, Dr. Tsoi’s research aims to develop analysis pipelines and computational approaches to provide biological inferences from genetics and genomics data. His work in genetic association studies revealed over 30 novel psoriasis susceptibility regions, and highlighted different disease pathways. He also led the analysis and developed computational pipeline to study psoriasis transcriptomes, and his work uncovered over 1,000 novel transcripts in skin.
Projects:
Psoriasis
University Affiliation(s)
UM-SBDRC
Research Area(s)
Genetics / Genomics / other OMICS
Publications
- Machine learning workflow to enhance predictions of adverse drug reactions through drug-gene interactions for cutaneous diseases
- Psoriasis-associated late cornified envelope (LCE) proteins have antibacterial activity
- Large Scale meta-analysis characterizes genetic architecture for common psoriasis-associated variants
Grants
- Co-investigator of: Activity of the IL-36 inflammatory axis in cutaneous lupus (DLE/SCLE)
- Principal investigator of: Personalized approach to enhance prediction of psoriatic arthritis
- Principal investigator of: Identification of psoriasis-associated IncRNAs through systems biology framework