Dr. Chinnaiyan’s laboratory is focused on using functional genomic, proteomic, metabolomic, and bioinformatics approaches to dissect and understand cancer biology as well as discover biomarkers. He and his collaborators have characterized a number of biomarkers of prostate cancer, including AMACR, EZH2, hespin, and sarcosine. His laboratory identified recurrent gene fusions of TMPRSS2 to ETS family transcription factors in prostate cancer, potentially redefining the molecular basis of prostate cancer as well as other common epithelial cancers. His laboratory developed the popular cancer profiling bioinformatics resource called Oncomine.