PhD, Chemical Engineering
Our Laboratory is focused on both experimental and theoretical aspects of cellular and molecular tissue engineering, metabolic engineering, and biomedicine, with an emphasis on clinical applications. Our research interests lie in the systems biology of metabolic diseases, specifically cancer. Our aim is to understand the role of metabolism in cancer progression, growth, and metastasis. We use genetic and metabolic design principles to analyze healthy and diseased biological states. We are working to uncover the metabolic interactions between cancer cells and cells in neighboring tissue that support cancer growth and metastasis. Our research integrates both experimental and computational tools to develop a recipe for maintaining normal function of various organs. Our lab also makes a concerted effort to use engineering principles, such as multi-objective optimality and non-equilibrium thermodynamics, to develop mathematical models for analyzing and understanding complex disease states. The outcome of our work is to discover potential therapies that exploit metabolic vulnerabilities in cancer.
Metabolic Liquid Biopsy to Predict Treatment Response in Non Small Cell Lung Cancer
University of Michigan
Metabolic Systems Biology | Other
- Principal investigator of: Implications of Metabolic Regulation of BCL-2 Dependence for Myeloma Therapy
- Principal investigator of: Uncovering Role of Exosomes in Regulating Pancreatic Cancer Cell Metabolism
- Principal investigator of: Identification of USP13 as a therapeutic target for ovarian cancer