Richard and Susan Rogel Professor of Oncology
BS, Veterinary Science, University of California-Davis
DVM, Veterinary Medicine, University of California-Davis
MPVM (Masters Preventive Veterinary Medicine), Epidemiology, University of California-Davis
PhD, Developmental Biology, University of Wisconsin-Madison
Evan T. Keller, DVM, PhD, is a Professor of Urology and Pathology, School of Medicine, University of Michigan. He is Associate Director for Shared Resource for the University of Michigan Comprehensive Rogel Cancer Center; Directs an NIH-funded Program Project on Prostate Cancer Bone Metastasis; is Director of the Single Cell Spatial Analysis Program; and is Co-Director of the Single Cell Analysis Core. His areas of research include (1) prostate cancer metastasis research, with a special emphasis on bone metastasis and the tumor microenvironment, and (2) single cell and spatial analytic methods. Key research accomplishments include (1) defining importance of osteoclastic activity and targeting it in prostate cancer, leading to clinical use of RANKL inhibitor (Denosumab); (2) identification of raf kinase inhibitor protein (RKIP) as a novel metastasis suppressor gene; (3) determining the importance of the Wnt pathway in bone metastasis; and (4) defining interleukin-6 as a contributor to castration resistant prostate cancer.
Mechanisms of chemoresistance; Tumor upgrading