Jorge Ruas, Pharm.D., Ph.D.
He/Him
Professor
Medicine
After receiving my Pharm.D. from the University of Lisbon, I received my PhD in Medical Sciences at Karolinska Institutet (KI) in 2005. After a postdoc at Harvard Medical School I started my research group at KI, became Associate Professor in 2016, and Professor of Molecular Physiology in 2020. In 2023 I joined the Department of Pharmacology and The Stanley and Judith Frankel Institute for Heart & Brain Health at the University of Michigan Medical School as Professor of Pharmacology. Our lab aims to identify the molecular mediators of the health benefits of exercise and to use this knowledge to develop novel disease therapies.
Projects:
Genetics and Epigenetics of Cardiovascular Disease and Dementia, Genetics of Obesity, Metabolomics of Early Cardiovascular Disease, Metabolomics of Insulin Resistance
University Affiliation(s)
Stanley and Judith Frankel Institute for Heart & Brain Health
Community and Professional Affiliation(s)
ADA | Endocrine Society
Research Area(s)
Diabetes and management | Disease Modeling | Metabolic Systems Biology | Obesity | cardiovascular diseases | mental health
Publications
- Comparative Analysis of Skeletal Muscle Transcriptional Signatures Associated With Aerobic Exercise Capacity or Response to Training in Humans and Rats
- The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1alpha/ATF6alpha complex
- HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
Grants
- Funded by: RUAS, Jorge L
- Consultant on: Leveraging adipose response to mitigate peripheral injury due to alcohol misuse