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Matthias Truttmann, Ph.D.


Assistant Professor

I was born and raised in the beautiful Swiss Alps between picturesque lakes and mountains. For my undergraduate and graduate training, I joined University of Basel, where I obtained a masters degree in Biochemistry/Biophysics before completing a Ph.D. in Microbiology under the supervision of Dr. Christoph Dehio. Following two years in the consulting industry, I then joined the laboratory of Dr. Hidde L Ploegh at Whitehead Institute for Biomedical Research/MIT for my postdoctoral training. As a postdoctoral fellow, I studied the physiological role of a novel post-translational protein modification, called AMPylation, in proteostasis. In summer 2018, I joined the department of Molecular & Integrative Physiology at University of Michigan Medical School as an assistant professor. At Michigan, my laboratory focuses on the physiological role of post-translational chaperone regulation, particularly AMPylation, in the context of aging, neurodegeneration, and cardiovascular diseases. We are also engaged in the development of novel nanobodies for biomedical research.


FICD variants in disease

Research Area(s)

Development and Aging