Matthias Truttmann, Ph.D.
He/Him
Assistant Professor
Medicine
I was born and raised in the beautiful Swiss Alps between picturesque lakes and mountains. For my undergraduate and graduate training, I joined University of Basel, where I obtained a masters degree in Biochemistry/Biophysics before completing a Ph.D. in Microbiology under the supervision of Dr. Christoph Dehio. Following two years in the consulting industry, I then joined the laboratory of Dr. Hidde L Ploegh at Whitehead Institute for Biomedical Research/MIT for my postdoctoral training. As a postdoctoral fellow, I studied the physiological role of a novel post-translational protein modification, called AMPylation, in proteostasis. In summer 2018, I joined the department of Molecular & Integrative Physiology at University of Michigan Medical School as an assistant professor. At Michigan, my laboratory focuses on the physiological role of post-translational chaperone regulation, particularly AMPylation, in the context of aging, neurodegeneration, and cardiovascular diseases. We are also engaged in the development of novel nanobodies for biomedical research.
Projects:
FICD variants in disease
Research Area(s)
Development and Aging
Publications
- Simultaneous analysis of large-scale RNAi screens for pathogen entry
- Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides
- Deletion of the AMPylase mFICD alters cytokine secretion and affects cognitive plasticity in vivo
Grants
- Funded by: TRUTTMANN, Matthias C
- Funded by: TRUTTMANN, Matthias C
- Principal investigator of: The mechanistic basis of HSC70 regulation and function