Rajasree Menon, PhD
Associate Research Scientist
Medicine
PhD
My main research is focused on studying alternative splice isoforms/variants that are involved in different types of human cancers. I have developed an approach to integrate transcriptomic data with mass-spectrometric data for the identification of splice isoforms. The functional role of the distinct splice variant of a gene is not well understood. I use different computational tools to understand the potential functions and interactions of these variants. I collaborate with other University of Michigan cancer specialists to experimentally validate our splice variant predictions in human normal and tumor tissue samples.
Research Area(s)
Computational Biology | Systems biology
Publications
- A functional annotation of subproteomes in human plasma
- Data management and preliminary data analysis in the pilot phase of the HUPO Plasma Proteome Project
- Overview of the HUPO Plasma Proteome Project: Results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database
Grants
- Co-investigator of: Kidney disease mechanisms associated with human genetic variation
- Co-investigator of: Tissue based integrative biology of early diabetic kidney disease in youth-onset type 2 diabetes
- Co-investigator of: Kitlg in glomerular disease and fibrosis