Member Database

Stephanie Bielas, PhD

Morton S. and Henrietta K. Sellner Endowed Professorship in Human Genetics
Human Genetics

PhD, University of California, San Diego

Research in the Bielas lab is aimed at understanding the epigenetic and molecular mechanisms of stem cell multipotency, self-renewal and neurogenesis required to build a brain. We develop these project from our human genetic studies aimed at identifying the genetic basis of neurodevelopmental disorders. A major challenge to investigating cell and molecular mechanisms of neurodevelopmental disorders has been the lack of affected tissue. To address this problem we use human brain organoid cultures, differentiated from human pluripotent stem cells (hPSCs) and transgenic mice as model systems. Our goal is to elucidate the pathology of clinically important neurological disorders and novel features of human brain development.


Genetic modulators of opioid exposure in human neurologic development

Community and Professional Affiliation(s)


Research Area(s)

Disease Modeling | Genetics / Genomics / other OMICS | Other


  • Principal investigator of: Neurogenesis: Career Development Plan in the Genetic and Modeling of Microcephaly
  • Co-investigator of: PRDM16 function in neural development
  • Principal investigator of: ASXL3 in Neural Fate Commitment and Autism Spectrum Disorder
View all grants